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One-shot Covid-19 vaccine developed at Beth Israel not as effective as two-shot vaccines

Associated Press reports Johnson & Johnson's proposed shot, which can be stored in a regular refrigerator and is 66% effective against moderate to severe Covid-19 symptoms, compared to around 95% for vaccines already in use from Moderna and Pfizer.

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Another way to look at it: A new vaccine will soon be available in a one-shot formulation, without the onerous cold-chain requirements of Moderna or Pfizer. It's actually been shown to be 72% effective in the U.S., against our current variants. We are so limited in supply now that any additional vaccines, particularly those that can be more easily administered in rural areas, will be a powerful tool in controlling this pandemic. The bigger issue will be that J&J needs to ramp up production.

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After day 28, no one who got vaccinated needed hospitalization or died regardless of whether they were exposed to “regular COVID or these particularly nasty variants,”

In that sense, the vaccine is proven 100% effective.

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False information. 223 died so far from vaccine. Check the vaers report that was updated today.

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If you take a million people aged 75, about 30,000 of them will not make it to their 76th birthday. Given that we're vaccinating the elderly and seriously infirm first, the reality is we're going to see tons of 'died shortly after receiving the vaccine' even if the vaccine was a saline shot.

The reality is the vaccine probably isn't 100% safe, but the data seems pretty clear that it's orders of magnitude safer than getting Covid. And the reality is that in the next 12-24 months you are going to get one or the other. Unless you're a Zoomer the shot is the far better bet and even for them it's probably the right one.

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Sure, us wealthy Westerners will still get Moderna or Pfizer, but think of the lives saved in 3rd world countries.

Great day for humanity.

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In my experience, there are a lot of places in the U.S. that are not wealthy, and will have trouble with the logistics of the cold chain storage. It's not just having a freezer, but scheduling all the patients to come in for the first shot, and then later return for the booster, within the time period after the vials are thawed.

Some people with mobility or transportation challenges will prefer a one-shot regimen as well.

To control the pandemic, we do need to figure out how to vaccinate around the world, though -- I agree that the J&J looks promising for that.

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I will be interested in seeing the results of the 2-dose study they are currently conducting. Right now, I would definitely want either the the Moderna or Pfizer vaccine but this is an important option for places where the required cold storage often isn't available, such as many countries with fewer resources than we have here.

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Do people eligible at this point get to choose between the two available vaccines or is it just luck of the draw? I know there’s no real difference but when J&J gets added into the mix I can see people refusing it & insisting on Pfizer or Moderna just based on the percentages. Of course, this will depend on how well the J&J vaccine is explained to the public

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I work at a hospital, and have gotten my first shot (second one is scheduled for a couple of weeks from now.) They were administering both vaccines, and which one you got was luck of the draw.

They had color-coded cards that they gave out (red for Moderna and blue for Pfizer or some such), which recipients had to hold onto until someone came by during the mandatory 15-minute wait-for-an-allergic-reaction period and scheduled the second shot.

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Maybe the one-shot should be for people who wear one mask, and the two-shot for double-makers.

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That's about the effectiveness of the normal flu shot every year, and well worth getting into people's arms ASAP -- particularly in places the cold storage is prohibitive

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If you are in one of the high risk groups (i.e., those getting shots now) the previously approved vaccines would probably be best. For those of us who would probably have a mild reaction to the virus, we could probably get this shot and go on with our lives. Same as the flu shot. I only started getting the flu shot to avoid giving others the flu.

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Is less than a 10 minute walk from my job.
Are they looking for volunteers?

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